Heart Hormones, Inversions, and Immortality

“Marshalling the information needed to optimize our own development runs counter to the program of our technical-scientific culture, which prefers to believe that degeneration is programmed, while emergent evolution is unforeseeable. But, if an optimization project is presented as a way to forestall the “programmed degeneration,” it might succeed in becoming part of the culture.”

-Ray Peat

 

alpāhāro yadi bhavedaghnirdahati tat-kṣhaṇāt |
adhaḥ-śirāśchordhva-pādaḥ kṣhaṇaṃ syātprathame dine || 81 ||

kṣhaṇāchcha kiṃchidadhikamabhyasechcha dine dine |
valitaṃ palitaṃ chaiva ṣhaṇmāsordhvaṃ na dṝśyate |
yāma-mātraṃ tu yo nityamabhyasetsa tu kālajit || 82 ||

 

“If he stints his diet, the fire quickly consumes [the body]. On the first day he should stand for a moment on his head, with his feet above.

After six months, the wrinkles and grey hair are not seen. He who practises it daily, for one yama (3 hours), conquers death.”

 

-from the Hatha Yoga Pradipika by Swatmarama (in reference to the Headstand / Viparita karani Mudra).

Dharma Mittra in headstand

Dharma Mittra in headstand

            So yet again those degenerate Hatha Yogis obsessed by the body and materiality are making outlandish and absurdly inflated claims for their circus tricks, before we saw how they claimed pranayama can cure all disease, now they expect prudent and reasonable human beings to believe that standing on your head will make you immortal, whatever next, yoga can turn you into an Elf?

If you believe in a biology crafted out of the random chance errors of a clockwork horror story “red in tooth and claw” then the claims made by some Hatha Yogis as well as other devils might appear insane, however taking another perspective on biology the picture is very different. In an organismic model where the liquid crystalline structure is generated and supported by the controlled coherent fire of the respiratory whirlwind, where processes are interconnected across all scales, then it might be possible to make creative use of local effects to generate systemic changes which further modify local processes. A range of relatively simple techniques for generating creative constructive adaptation that is capable of overcoming the organism’s assimilated inertia might make themselves available.

I believe that Hatha Yoga is an art that has discovered such creative techniques, and increasingly the evidence exists to make this case.

The Natriuretic peptides are a class of hormones secreted by the heart, while they are named for the observation that they can increase the urinary elimination of sodium they have a range of much more interesting effects. A major stimulus for their release is the stretching of the chambers (atria and ventricles) of the heart (Espiner et al.1995).

There is some evidence that inversions (turning upside down) cause an increased stretch in the chambers of the heart, as might be expected. A study examining the circulatory effects of the head down position showed increases in stroke volume, and cardiac output and a decrease in pulse rate (Wilkins et al. 1950). A study looking specifically at the yoga postures Sirshasana (headstand) and Sarvangasana (shoulderstand) found a significant increase in early left ventricle filling, a shortening of the isovolumetric relaxation time and an increase in heart rate (Minvaleev et al. 1995). If inversions are stretching the hearts chambers then they should be stimulating the release of the Natriuretic peptides, as far as I am aware no studies have looked at this possibility so there is some speculation here.

The Cardiac natriuretic peptides include six hormones stored as three separate prohormones, Atrial Natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). ANP contains: long-acting natriuretic peptide (LANP), vessel dilator, kaliuretic peptide, and ANP (Vesely 2006).

The Natriuretic peptides have a wide range of effects, they have been shown to be anti-inflammatory, ANP reduced the secretion of inflammatory mediators produced in response to bacterial endotoxin /lipopolysaccharide (Kiemer and Vollmar 2001). Both ANP and CNP reduced the expression of COX-2 and prostaglandin E2 (PGE2) in response to lipolysaccharide (Kiemer et al. 2001). Anti-fibrotic , mice lacking BNP develop multiple fibrotic lesions (Tamura et al. 2000), BNP also appears to inhibit the profibrotic TGF-ß and increased collagen 1 and fibronectin proteins (Kapoun et al. 2004). ANP appears to have a tissue stabilising effect that prevents leakiness, ANP inhibited VEGF (vascular endothelial growth factor), protected the integrity of the blood-retinal-barrier of rats, ANP also significantly reduced the damage done by laser injury (being a lab rat sucks) ( Lara-Castillo et al. 2009). ANP has been found to defend the endothelial barrier from histamine induced permeability (Fürst et al. 2008).

These cardiac peptides appear to have some significant anti-cancer activity, in 24 hours, Vessel dilator, LANP, Kaliuretic peptide and ANP decreased the number of human pancreatic adenocarcinoma cells in culture by 65%, 47%, 37% and 34% respectively. Vessel dilator completely stopped the growth of human pancreatic adenocarcinomas in mice, further decreasing the size of even palpable large tumors, after 1 week vessel dilator decreased the size by 49%, LANP by 28%, and kaliuretic by 11%, in placebo treated mice the tumor had increased in size by 20 fold.

These hormones also decreased the number of breast adenocarcinoma cells by 60%(vessel dilator), 31%(LANP), 27% (kaliuretic), 40% (ANP). Other cancers; decreased cell numbers of small cell lung cancer, squamous lung cancers, and malignant tumors of the heart (Vesely 2005).

A study examining the effects of CNP on proliferating smooth muscle cells found that CNP induced growth inhibition and promoted re-differentiation into highly differentiated smooth muscle cells rather than the less differentiated proliferative phase, CNP improved healing accelerating re-endotheliazation preventing neointima formation (Doi et al. 2001).

The cardiac peptides also decrease some hormones associated with stress, perhaps most interestingly prolactin (Samson et al. 1998), but also ACTH which contributes to cortisol (a catabolic hormone released by stress) release (Fink et al. 1991). Swatmarama states that headstand can reverse greying of hair, and prolactin has been implicated in hair loss (Foitzik et al. 2006).

These effects of the cardiac peptides, anti-inflammatory, tissue stabilising and anti-cancer suggest that it might be appropriate to view these hormones as in some sense bioenergetic kosmotropes that increase the coherence of the organism, as Energy and structure are interdependent, at every level”* then substances that increase structural coherence should in some way increase energy as an increase in structure should allow for an increase in energy flow which would in-turn allow for structural complexification.

ANP and BNP have been found to induce mitochondriogenesis (making new mitochondria) , and to increase “uncoupled” respiration, that is to increase respiration without producing ATP, instead increasing heat production, and increasing energy expenditure. White adipose tissue appeared to become more like brown fat tissue, brown fat contains more mitochondria than white, and is especially abundant in infants, increased levels and activity of brown fat has been linked to resistance to metabolic diseases such as diabetes and obesity (Bordicchia et al. 2012). A separate study found that BNP protected against diet induced obesity and insulin resistance and increased muscle mitochondrial content (Miyashita et al. 2009).

With the prevalence of mechanical thinking in biology some people might think that increased metabolism means increased wear and tear on the lumbering bio-robot that is piloted by their consciousness (probably an illusion generated by those selfish genes), if the organism is generated by the metabolic flow of energy, the increased metabolism would be expected to result in increased renewal and rejuvenation. In mice individuals with higher metabolisms and greater mitochondrial uncoupling lived longer (Speakman et al. 2004). Somewhat obviously disuse of a tissue results in atrophy, and mitochondria demonstrate increased reactive oxygen species (ROS) and decreased respiratory enzymes.

Given the evidence for the role of intensified metabolism in evolutionary progress it seems especially difficult to take seriously any attempt to market torpor as a preferable biological state. Mammals have more intense metabolisms than reptiles from 2 to 5 times more, possibly even greater in the case of some humans, mammals also have greater thyroid activity than reptiles (Hulbert and Else 1981). This increased metabolic activity in mammals has required adaptative complexification of the cardiopulmonary system to support it, this is one of the clearest examples of aromorphosis (a raising of the shape making a higher level of function available), an increased metabolism and increased oxygen use required a development and complexification of the Heart and circulatory system, the generation of a four chambered heart made it possible to operate at a higher, more generous energy level. Generally, fish have a two chambered heart, amphibians three chambers, two atria and one ventricle, from here things get a little more complicated as many species of reptile have varying degrees of ventricular septation, meaning that blood flow can complexify and increase in efficiency but not to the degree of birds, and mammals which have four chambered hearts (Jensen et al. 2013).

Morphology of the heart of various animals (Jensen et al. 2013)

Morphology of the heart of various animals (Jensen et al. 2013)

I think the case can be made that the cardiac peptides are sorts of morphogen, substances that are involved in biological structure generation and regulation, which would be dependent on available energy, decreased energy tends to result in a sort of organismic shrinking, and poor circulation, the effects of an energy surplus can be felt after a large meal, a sort of pleasant expansive, metabolic flush, an increase in circulation, pranayama also can produce such an effect, which should result in increased stretch being experienced in the heart. It seems reasonable to suggest the heart as sort of morphogenic regulator.

These Cardiac peptides are higher in the foetal circulation than adults, and the foetal heart expresses higher levels of these hormones than the adult heart. Peaks of ANP and BNP during gestation coincide with significant moments during cardiac morphogenesis (Cameron and Ellmers 2003).

These peptides also appear to play a role in bone remodelling, CNP is a potent stimulator of osteoclast activity demonstrating a role in bone remodelling (Holliday et al. 1995). CNP also stimulates chondrocyte proliferation, cartilage matrix production and long bone growth in foetal rats (Mericq et al. 2000).

If these cardiac peptides are sorts of morphogen then they might be expected to be increased by other signs of increased energy availability, such as increased thyroid activity and steroid hormones this appears to be the case, thyroid hormones T3 and T4 (T3 being more active) and testosterone dose dependently stimulated ANP (Matsubara et al. 1987). ANP at least in some studies stimulates testosterone production (Pereira et al. 2008), I think this points to the possibility of some self-intensifying positive feedback loops at least when energy is available to nurture them. Life appears to desire to be ever more.

“Energy is the only Life…”

*apologies to Ray Peat for totally overusing this quote (the “Energy and structure…”one), and also for the neural architecture I stole, you can’t have it back, and anyway I fear it’s been irreversibly warped by my own context.

References

Bordicchia M, Liu D, Amri E-Z, Ailhaud G, Dessi-Fulgheri P, Zhang C, Noboyuki T, Sarzani R, Collins S, (2012), Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes, J Clin Invest, 122(3), pp 1022-1036.

Cameron VA, and Ellmers LJ, (2003), Minireview: natriuretic peptides during development of the fetal heart and circulation, Endocrinology, 144(6).

Doi K, Ikeda T, Itoh H, Ueyama K, Hosoda K, Ogawa Y, Yamashita J, Chun T-H, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, Saito T, Sone M, Yamahara K, Kook H, Komeda M, Ueda M, Nakao K, (2001), C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendotheliazation, Arteriosclerosis, Thrombosis, and Vascular Biology, 21, pp. 930-936.

Espiner EA, Richards AM, Yandle TG, Nicholls MG, (1995), Natriuretic hormones, Endocrinology and Metabolism Clinics of North America, 24(3), pp. 481-509.

Fink G, Dow RC, Casley D, Johnston CI, Lim AT, Copolov DL, Bennie J, Carroll S, Dick H, (1991), Atrial natriuretic peptide is a physiological inhibitor of ACTH release: evidence from immunoneutralization in vivo, J Endocrinol, 131, pp. 9-12.

Foitzik K, Krause K, Conrad F, Nakamura M, Funk W, Paus R, (2006), Human scalp hair follicles are both a target and a source of prolactin which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression, American Journal of Pathology, 168(3), pp. 748-756.

FürstR, Bubik MF, Bihari P, Mayer BA, Khandoga AG, Hoffman F, Rehberg M, Krombach F, Zahler S, and Vollmar AM, (2008), Atrial natriuretic peptide protects against histamine-induced endothelial barrier dysfunction in vivo, Molecular Pharmacology, 74(1), pp. 1-8).

Holliday LS, Dead AD, Greenwald JE, Gluck SL, (1995), C-type natriuretic peptide increases bone resorption in 1,25-dihydroxyvitamin D3- stimulated mouse bone marrow cultures, Journal of Biological Chemistry, 270, pp. 18983-18989.

Hulbert AJ, and Else PL, (1981), Comparison of the “mammal machine” and the “reptile machine”: energy use and thyroid activity, AJP- Regu Physiol, 241(5), pp. 350-356.

Jensen B, Wang T, Christoffels VM, Moorman AFM, (2013), Evolution and development of the building plan of the vertebrate heart, BBA- Molecular Cell Research, 1833(4), pp.783-794.

Kapoun AM, Liang F, O’Young G, Damm DL, Quon D, White RT, Munson K, Lam A, Schreiner GF, Protter AA, (2000), B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-ß in primary human cardiac fibroblasts, Circulation Research, 94, pp. 453-461.

Kiemer AK, and Vollmar AM, (2001), The atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages, Ann Rheum Dis, 60, pp. 68-70.

Kiemer AK, Lehner MD, Hartung T, and Vollmar AM, (2001), Inhibition of Cycloxygenase-2 by natriuretic peptides, Endocrinology, 143(3).

Lara-Castillo N, Zandi S, Nakao S, Ito Y, Noda K, She H, Frimmel S, Ablonczy Z, Hafezi-Moghadam A, (2009), Atrial natriuretic peptide reduces vascular leakage and choroidal neovascularisation, Am J Pathol, 175(6), pp. 2343-2350.

Matsubara H, Hirata Y, Yoshimi H, Takata S, Takagi Y, Iida T, Yamane Y, Umeda Y, Nishikawa M, Inada M, (1987), Effects of steroid and thyroid on synthesis of atrial natriuretic peptide by cultured atrial myocytes of rat, Biochemical and Biophysical Research Communications, 145(1), pp. 336-343.

Mericq V, Uyeda JA, Barnes KM, de Luca F, and Baron J, (2000), Regulation of fetal rat bone growth by C-type natriuretic peptide and cGMP, Pediatric Research, 47, pp. 189-193.

Minvaleev RS, Kuznetsov AA, Nozdrachev AD, Lavinskii YK, (1995), Left ventricle filling in sirsasana and sarvangasana yogic postures, St Petersberg State University.

Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T, Nakao, K, (2009), Natriuretic peptides / cGMP/ cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity, Diabetes, 58(12),pp. 2880-2892.

Pereira VM, Costa APR, Rosa-e-Silva AAM, Viera MAR, dos Reis AM, (2008), Regulation of Steroidgenesis by atrial natriuretic peptide (ANP) in the rat testis: differential involvement of GC-A and C receptors, Peptides, 29(11), pp. 2024-2032.

Samson WK, Bianchi R, Mogg R, (1988), Evidence for a dopaminergic mechanism for the prolactin inhibitory effect of Atrial Natriuretic factor, Neuroendocrinology, 47, pp. 268-271.

Speakman JR, Talbot DA, Selman C, Snart S, McLaren JS, Redman P, Krol E, Jackson DM, MS Johnson, Brand MD, (2004), Uncoupled and surviving:individual mice with high metabolism have greater mitochondrial uncoupling and live longer, Aging Cell 3(3), pp. 87-95.

Tamura N, Ogawa Y, Chusho H, Nakamura K, Nakao K, Suda M, Kasahara M, Hashimoto R, Katsuura G, Mukoyama M, Itoh H, Saito Y, Issei T, Hiroki O, Katsuki M, Nakao K, (2000), Cardiac fibrosis in mice lacking brain natriuretic peptide, PNAS, 97(8),pp. 4239-4244.

Veseley D, (2005), Atrial natriuretic peptides: anticancer agents, Journal of Investigative Medicine, 53(7), pp. 360-365.

Veseley D, (2006), Which of the cardiac natriuretic peptides is most effective for the treatment of congestive heart failure, renal failure, and cancer? Clinical and Experimental Pharmacology and Physiology, 33(3), pp. 169-176.

Wilkins RW, Bradley SE Friedland CK, (1950), The acute circulatory effects of the head-down position (negative G) in normal man, with a note on some measures designed to relieve cranial congestion in this position, J Clin Invest, 29(7), pp.940-949.

The Starchild Skull: a third perspective, aromorphic evolution?

“He whose face gives no light shall never become a star.”

-William Blake

“Every man and every woman is a star.”

-Aleister Crowley

“The infant represents our evolutionary future.”

-Ray Peat 

 

Aromorphosis: noun; plural aromorphoses; from Greek airein, to raise; morphosis, shaping.  An advancement in the organization of an organism, without a marked increase in specialisation; an aromorph.

“a morphological and physiological process, one of the main trends in the biological progress of living organisms whereby their organization becomes increasingly complicated in the course of evolution. The term was introduced by A. N. Severtsov, who used the word “aromorphosis” to refer to the most general adaptive changes in organization and functions. Aromorphosis is usually accompanied by an increase in the intensity of the life processes of animals and in the variety of their manifestations (differentiation)…. Aromorphosis enables qualitative jumps that raise the level of organization of a species…. As an example of aromorphosis in the evolution of higher vertebrates Severtsov cites the qualitative jump in the transition from reptilian ancestors to mammals. The four-chambered heart, the alveolar structure of the lungs, diaphragmatic breathing, and other factors raised the level of metabolism in mammals and increased their ability to adapt to changes in living conditions. Bearing young in the mother’s uterus and feeding them milk extended their chances of survival.”

from The Great Soviet Encyclopedia (1979).

 starskull

The Starchild skull is a strange skull that was found in Mexico, somewhere between the region of the Sierra Madre Occidental mountain range (elevation: 10,863ft / 3,311 m), and about 100 miles southwest of Chihuahua, the skull appears to be around 900 years old according to radiocarbon dating. The skull exhibits a number of very unusual features leading to claims that it is either alien or a human-alien hybrid, the most notable proponent of the alien/ alien-human hybrid explanation was the late Lloyd Pye, on the other hand the “sceptics” claim the skull is simply a deformed human skull, one that admittedly exhibits a range of unusual features. I’m not convinced either of these two positions is true and would like to suggest a third tentative :) possibility.

First the unusual features of the skull:

starchild-skull-multi-view

The volume of the interior of the skull is 1,600 cubic cm, 200cm3 larger than the average adult’s and 400cm3 larger than an adult of equivalent size.

star-child-and-human-skulls-1

The orbits of the eyes are oval and unusually shallow.

It appears the skull would have had relatively small cheek bones and small muscles for chewing food as these muscles pass through the zygomatic arches.

cheekbones

The skull lacks frontal sinuses.

The bone is unusually thin, but also appears to be highly durable, exceptionally hard, Lloyd Pye has claimed that the bone was incredibly difficult to cut through and is woven through by odd fibres, yet to be identified.

A mineral analysis of the bone shows significant differences to typical human bone, most notably containing an unusually high amount of carbon and oxygen (carbon dioxide?).

mineral analysis

mineral analysis

Genetic material recovered from the skull appears unusual, mitochondrial DNA from the starchild skull differs from human, generally the maximum number of mtDNA variations between humans is 120. The Starchild Skull has between 800-1,000 differences.

Nuclear DNA, some of the starchild’s nuclear DNA may be different from anything previously found on earth, including a fragment several thousand nucleotides long that could not be matched to any recorded DNA.

There are some issues with the interpretation and presentation of results of genetic testing by the Starchild Project, early tests appeared to show that standard X and Y chromosomes were present, suggesting that the child was a human male or at least had human parents. Mitochondrial DNA also appeared to belong to haplogroup C (a Native American group).

I don’t think the possibly significant genetic differences require extra-terrestrials to explain, given the evidence for non-random directed genetic mutation, it seems possible that a biology that is liquid crystalline and energetically coherent across multiple domains would allow for sudden meaningful and significant adaptive evolutionary jumps especially when conscious organismic intelligence is recognised as fundamental to and inseparable from biology. Organismic bioenergetic coherence would allow for seemingly vast evolutionary jumps with the new organism differing significantly and meaningfully at the genetic level from the parent organism.

The early results also strongly suggest the skull at least has a connection to earth humans.

What I would like to suggest is that the skull is neither deformed nor alien, instead it may be neo/meta-human, an evolutionary stride forwards.

images-2

So why do I think this might be the case? Well the skull and some of the reconstructions based on it appear remarkably neotenous, that is it preserves very youthful features, large brain size, large, eyes, relatively small face in comparison to the head size, for more on neoteny as an evolutionary tendency see:

Chapter 4 of Ray Peat’s Generative Energy

And,

Ontogeny anticipates phylogeny: Evolution, meditation, and the brain.

 

Star_Child_Skull_reconstruction

I think the mineral analysis is interesting, if carbon dioxide is as biologically significant as I suspect, acting in some sense as a sort of electrical doping agent increasing the conductivity of proteins, it might be expected that a more evolved and energetic organism might show signs of exposure to higher levels of carbon dioxide.

For more on CO2 see:

Pranayama, Carbon Dioxide, Mitochondria, Coherent Energy Flow, Regeneration and Individuation

And

Rainbow worms, Electrobiology, Carbon Dioxide and the Streaming Auto Evolving Life Process

As well as Ray Peat’s articles and the Biology of Carbon dioxide video (see resources).

I think some of the unusual qualities of the bone might be explainable by increased trophic activity of the nerves, resulting in a more qualitatively developed bone as a result of increased quality of innervation, denervation of bone results in osteoporotic bone, so it does not seem unreasonable that increased nerve energy might result in a developmental advance in bone quality.

hydrocephalic skull

hydrocephalic skull

I’m not convinced by the explanation that the skull is of cradleboarded hydrocephalic infant, or a child with progeria, the morphology of the skull while unusual appears coherent and the unusual qualities of the bone, if Lloyd Pye has reported them accurately, seem incompatible with either hydrocephalus or progeria. In progeria bones show hypoplasia and dysplasia, yet the starchild bone is reported to be super-humanly tough.

I don’t think it’s necessary to bring extra-terrestrials into the picture to explain the starchild skull, other factors that might be involved include the altitude, leading to increased carbon dioxide retention on the part of both the child and mother, possible yogic / meditative / spiritual practice on the part of the mother resulting in an optimized uterine environment for the developing organism. If the skull is 900 years old this would place it within the Medieval warm period which lasted from AD 950 – 1250, in Europe this was a perid of abundant food as result of the warmer climate and milder winters, this abundance of food and more hospitable climate may have contributed to developments in art and culture that resulted in Gothic architecture, it is possible that these more nurturing conditions allowed for the aromorphic evolution seen in the Starchild skull. Other various and unknown reasons might also be involved, likely requiring a highly permissive environment free from the usual distorting cultural stressors a developing child would encounter, allowing for the child to devote its conscious energies to the realization and expansion of its developmental potentials, allowing for autopoietic evolution.

The suggestion that the starchild’s differences are a result of an autopoietic evolution might seem strange even impossible, but only if you believe in a stupid mechanical model of evolutionary change that depends on random mutations selected out by a blind mechanism “red in tooth and claw”, if it is recognized that evolution is a living organic participatory process that intimately involves conscious intelligence, then the suggestion that the starchild skull might be the result of a conscious organic probing into a new potential biopsychic state seems at least to me natural, and if this sort of evolution is possible for one then it must be possible for others.

Further Reading

 

A Bone to Pick with the Starchild Skull

The Starchild Project

 

The child’s toys and the old man’s reasons are the fruits of the two seasons.

“Once we accept that knowledge is tentative, and that we are probably going to improve our knowledge in important ways when we learn more about the world, we are less likely to reject new information that conflicts with our present ideas. The attitude of expectancy will allow us to apply insights gained at one level of generality to other levels. No particular kind of knowledge will have such authority that it will automatically exclude certain possibilities in another field of knowledge.”

-Ray Peat

 

I don’t think enough emphasis can be placed on the quote above from Ray, as we learn and discover more experience deepens and old models whilst accurate in at least some respects may need to be re-evaluated in reference to larger perspectives as they are experienced, attachments to old descriptions and interpretive frameworks may acts as blinders and binders of more vital perspectives that may be immediately available to direct experience if only the mind forged manacles can be cast off.

 

“When you believe that you have adequate, expert knowledge, a passive, logical, deductive form of mental activity seems appropriate. Deduction always goes from a higher level of generality to a lower level of generality. Mental passivity therefore is likely to be associated with the belief that we have the decisive knowledge already stored in memory. If we believe that we create higher degrees of generality, as appropriate solutions to novel problems, then we are committed to an active mental life. Perception, combined with the discovery and invention of new patterns in the world, will be actively oriented toward the future, while the deductive, merely analytical, manner of thought will be tied to the past.”

-Ray Peat

 

Remaining open to new perspectives encourages a youthful flexible mind, one that experiences the world intimately with a continual sense of wonder.

As we develop our world view must develop with us if our world view remains static it is likely that our possible growth and development is being inhibited.

 

The eagle never lost so much time, as when he submitted to learn of the crow.”

 

“As the true method of knowledge is experiment, the true faculty of knowing must be the faculty which experiences.”

 

 

“The ancient Poets animated all sensible objects with Gods or Geniuses, calling them by the names and adorning them with the properties of woods, rivers, mountains, lakes, cities, nations, and whatever their enlarged & numerous senses could percieve.
And particularly they studied the genius of each city & country, placing it under its mental deity;
Till a system was formed, which some took advantage of & enslav’d the vulgar by attempting to realize or abstract the mental deities from their objects: thus began Priesthood;
Choosing forms of worship from poetic tales.
And at length they pronounc’d that the Gods had order’d such things.
Thus men forgot that All deities reside in the human breast.”

Generative Energy Episode Five: Energy and Structure (Respiration vs. Fermentation and Coherence vs. Incoherence) — The Danny Roddy Weblog

Generative Energy Episode Five: Energy and Structure (Respiration vs. Fermentation and Coherence vs. Incoherence) — The Danny Roddy Weblog.

Danny Roddy talks with me about respiration from the perspective of Ray Peat and Gilbert Ling, as well as talking about a dynamic liquid crystalline view of biology as found in Mae-Wan Ho’s work.

William Blake and other biopsychic visionaries: Imagination, energy, and alchemy.

“Art is the tree of life. Science is the tree of death.”

 “Energy is the only life, and is from the Body and Reason is the Bound or outward circumference of Energy.”

“Energy is eternal delight.”

“What is the life of Man but Art and Science?”

“The imagination is not a state: it is the human existence itself.”

 

“Truth can never be told so as to be understood and not be believed.”

-William Blake

 Self-Portrait-of-William-Blake

The imagination is typically seen as a sort of abstract fuzzy faint voluntary delusion generating faculty, however not all have seen the imagination in such terms, William Blake saw imagination as the defining human quality. Blake appeared to see Life as limitless magickal[666](and what is the imagination if not magical) innovation, imagination as an active conscious expression of living energy.

Blake saw reason and “science”, at least in their reductionist expression, as in opposition to the full expression of humanity, they were for Blake an expression of insanity, and I agree. Whilst psychosis and various forms of schizoid behaviour are typically considered forms of highly irrational behaviour, I think it might be more accurate to view such states as magnifications or intensifications of a particular kind of reasoning, one that has become divorced from intuition, and centred biopsychic perception and instead lost itself in a labyrinth of self-referential reasoning, a fairly common manifestation of this sort of madness is when an individual ceases to trust in their own will and creative choice, and instead attempts to “decode reality” through obsessively interpreting everything around them as sorts of omens or signs, from which to determine appropriate behaviour (usually resulting in highly inappropriate behaviour, often hilariously so, sometimes tragically), seemingly unable to trust in their own guidance systems. I think this is especially common in highly authoritarian cultures, as individuals are consistently taught that appropriate behaviour must come from an authority.

 

“The man reared under and bound by authority has no knowledge of the natural law of self-regulation; he has no confidence in himself. He is afraid of his sexuality because he has never learned to live naturally. Thus he declines all responsibility for his acts and decisions and demands direction and guidance.”

-Wilhelm Reich

 

The world for people caught up in such a state becomes both a sort of puzzle to decode, and once “decoded” a set of instructions to follow. Whilst such states are obviously transient, being simply a state of profound confusion, the current psychiatric medical model claims that individuals experiencing such states are “chemically unbalanced” as a result of… “genes”. The victim of this psychiatric bullying is told essentially that they are fundamentally defective, any attempts they might make to understand and deal with the situation themself are essentially useless, they must take the prescribed drugs (typically metabolic toxins), if the victim attempts to question the diagnosis and / or prescription, this is considered further compounding evidence of their “genetic” sickness (the technical terminology is that the patient “lacks insight”), the psychiatrist is after all an authority, and current medical psychiatry clearly understands the nature and infinite nuances of human consciousness (just in case you weren’t sure this is sarcasm). I think this forced drugging of psychiatric patients is a profoundly violent and dehumanising act. The psychiatric prison is a distillation of everything that is wrong with authoritarian culture. Psychiatry like the “war on drugs” appears to be  an attempt to limit free consciousness. Some psychiatrists appear to be playing out narcissistic power fantasies, having zero empathy for their patients/victims, for a “patient” questioning the authority and opinions of these shrinks is generally a bad idea.

The approach to life, outlined in the above description of a psychotic state, has a lot in common with the attitudes of some scientists, for example Rene Descartes appears to have taken such a view, seeing the world as a great machine operating according to fixed laws,

“Descartes had a dream and in this dream an angel appeared to him, this is documented by his own hand, and the angel said to Descartes, “The conquest of nature is to be achieved through measure and number.” And that revelation lay the basis for modern science.”

Within this mechanical world bound by measure and number the human soul interfaces with a mechanical body through the pineal gland alone, this dualism is opposed to Blake’s view, “Man has no Body distinct from his Soul”. Exactly how Blake would have seen Descartes “angel” is unknown, but I think Blake might have seen this “angel” as a representative of Urizen. Descartes was forced into this dualistic conception of body and soul because he viewed life as mechanical, the world was made of lumps of dead matter interacting through clunky mechanism, and at least realized that explaining the subtelties of mental experience through mechanism was no easy task, apparently today some “scientists”, have gone further than Descartes in such mechanical madness suggesting that,

“We are survival machines – robot vehicles blindly programmed to preserve the selfish molecules known as genes. This is a truth which still fills me with astonishment.”

-Richard Dawkins: The Selfish Gene

I’m also astonished, that someone can believe something like this, its absurd and explains less than nothing.

Dawkins is apparently unsure of whether animals are conscious, and has stated that consciousness (even human) may be an illusion. Again these insane views can be traced back to Descartes and those like him who denied that animals had souls seeing them as beast-machines, who did not really experience pain, the animals apparent experience of pain, a complex illusion, yelps or screams and attempts to avoid the source of injury, merely mechanistic reflexes emitted by an automaton. Blake found this view monstrous, his views on the “ensoulment” of animals are clear.

“A horse misused upon the road

Calls to heaven for human blood.

Each outcry of the hunted hare

A fibre from the brain does tear.

 

A skylark wounded in the wing,

A cherubim does cease to sing.

The game-cock clipt and arm’d for fight

Does the rising sun affright.”

-William Blake, Auguries of Innocence.

These “enlightened” scientists believe some fundamentally absurd things, all whilst claiming to be rational, though a very particular sort of rational, one that has chained reality in their own limited conceptions. As a result the “science” that has been engineered by these people is one that is dead, reflecting their own view of life back at them, justifying the moronic cruelties that are perpetrated in the name of “science”, animal experimentation and vivisection, justified because animals aren’t really conscious, just complex survival machines. This dead mechanical view of life and nature driven by random processes leads to our treating nature as lifeless, and in doing so we disrupt, sicken, and distort the web of Life that supports us. There is little evidence to support this mechanical view of life, which exists as an unquestioned dogma of contemporary science, derived to a large extent from “rational” deists like Descartes and Newton who viewed the Cosmos as a complicated clockwork automata created by a distant “divine watch maker.” This obsession with mechanical metaphor has been relatively constant, the absurdity of this view reaching its zenith in atheistic mechanists who believe in a clockwork universe comprised of teeny tiny, discrete, quantized, bits of dead unconscious matter, that some how jumbled together into amino acids that further jumbled together into solutions contained in sacks of water surrounded by oily membranes, these water sacks assembled into multicellular bio-machines, complexifying through a “biological” evolution driven by random mutations selected out by a crude mechanism “red in tooth and claw”, that eventually produced human beings, capable of producing art, music, painting, sculpture, architecture, and dance, this creativity some would have you believe is a product of a consciousness that is an illusory epiphenomenon. Furthermore this all takes place in vast, dead cosmos that was born once upon a time when nothing exploded (the Big Bang?!?), the deistic conception of the universe is bizarre, the reductionist view insane (“the limit test for credulity”), strangely such ideas are treated as reasonable.

“For approximately 500 years [science’s] argument for its pre-eminence was that it could create beautiful toys: aircraft, railroads, global economies, television, spacecraft. But that is a fool’s argument for truth! I mean, that’s after all how a medicine show operates, you know: the juggler is so good, the medicine must be even better! This is not an entirely rational way to proceed.”

-Terrence McKenna

 Newton-WilliamBlake

This mechanical view of life is also a very convenient myth, historically (and still today) the pseudo Darwinian mechanical evolutionary model has appealed to ruling classes, seeking justification for their dominance. The genetic determinist paradigm being essentially a rebranding of eugenics. This myth supports the interests of corporatism, leading to vastly wasteful research into profitable disease treatments, not cures, a patient cured is a customer lost.

Evolution of both organisms and the biosphere is absolutely purposeful, and of course purpose requires intelligence, no purpose without mind or intention. To suggest that All that we see around us has come about by blind, random, chance, is well staggeringly stupid, a person does not achieve accomplishment of any sort through random chance, will, directionality is involved, choice, would biology be any different?.

“Passively taking whatever you are given, by history and nature, is entropic; choosing intelligently from possible diets, selecting courses of action, will create pattern and reduce entropy.”

-Ray Peat

To suggest that humans have come about through random chance mutations seems insane, we are purposeful, and all those who have contributed in any way to what human civilisation we have, have consciously lived with purpose.

Purpose is negentropic / Kosmotropic, we see in this world, despite the monstrous stupidity, the ecological disasters and wars wrought by human ignorance, there is order, Kosmos, biological Life.

Further we see evidence that biology both organisms and the biosphere have qualitatively evolved becoming ever more complex, ever more, energetic, ever more conscious and aware.

Adults would be expected to be more individuated than children, however this requires a sort of choice, an exploratory expansion into possibility, the general culture opposes this on multiple levels, the inevitability of distorting trauma seems almost inescapable, learned helplessness is ubiquitous and an individual’s free growth is frustrated through a  toxic culture that blinds people to their own potential. Adults often appear to have suffered a sort of dedifferentiation, the free expression of their own vital creative energy having been hindered by the cultural environment.

To suggest that the Life we see around us has become what it is without purpose seems absurd, an absolute denial of reality, and yet this is the position that is treated as reasonable by mainstream science, praise be to Random Chance!

The mechanical model obviously contributes to the problems of psychiatry, beyond categorising individuals struggling to effectively orient themselves within a deranged antihuman culture as mysteriously “chemically imbalanced” and genetically defective, it also automatically discounts the possibility that some individuals may in fact have more finely tuned sensory capacities, if a person hears things or sees things that others don’t the assumption is that they are crazy, this problem is compounded by the distinct possibility that if someone was to find their sensory abilities very suddenly becoming more refined, and plunged into perceptions they had previously not experienced, their ability to orient themselves to these new perceptions might at first be a little shaky, like a child learning to walk, it seems likely that they might have a few falls as they learn to orient themselves to these new perceptual capacities.

 

“Indubitably, Magick is one of the subtlest and most difficult of the sciences and arts. There is more opportunity for errors of comprehension, judgement and practice than in any other branch of physics.”

-Aleister Crowley

William Blake claimed to see visions, and hear voices, at times finding these experiences disturbing, he eventually integrated them into his life and was enriched by them. The general consensus of many of his contemporaries was that Blake was charming, though quite mad.

Much of modern science is self-limiting, it has imposed false limits on reality, jumped to conclusions about the nature of Life that are groundless, based only on the dull preconceptions of limited minds that argue noisily for them, genetic determinism and the idea that consciousness is an epiphenomenon arising from electrically firing neurons, are perhaps the most problematic example of this. When people are taught that their identity is determined by genes, and that their consciousness is complicated illusion, that they are inconsequential, an accident adrift in cold dead Cosmos, a passive attitude is encouraged, this attitude renders them easily manageable on large scales, if life is dead mechanistic matter then why seek anything outside of the culturally approved entertainments.

“Reason, or the ratio of all we have already known, is not the same that it shall be when we know more.”

Blake was critical not only of reductionist science but conventional religion, which he saw as Life-denying curse, the body and sensual experience seen as sinful distractions, the material world for the religious was just a dead world created by “Old Nobodaddy aloft”, the idea of God as the distant Grand Architect, was for Blake madness, such an idea could not describe true Divinity but only a half mad demiurge, the limited and limiting, Urizen. These life-denying interpretations of religion have oddly enough formed the basis of the current secular reductionist tendencies in science.

These dualistic conceptions, that propose either a physical world created by a distant sky giant, with a vaporous metaphysical soul interacting with an earthen body through the pineal gland, or a world of dead matter, with consciousness as an illusory epiphenomenon have contributed to the gross stupidities that currently endanger all life on this planet.

If instead we were to imagine that consciousness was the fundamental property of Life, intrinsic to biology, how would this affect our approach to life? If all things that live are conscious surely that means that we share in this experience with them, if “worms and flies and ants are conscious and in the same situation as human beings, the bonds of sympathy and forgiveness are universal.”

I think it is possible that the greatest evidence for a living Kosmos is the sensitivity of the human nervous system, a sensitivity that simply cannot be explained by the mind numbingly stupid explanations of conventional biology reliant on nerves functioning through binary all or nothing signalling, mediated through the actions of mechanical “pumps” installed in fatty membranes. To believe that this model of nerve biology explains the exquisite sensitivity that we experience through our various senses, the vision of the iridescent peacock’s tail, the deeply nuanced sense of hearing that allows for the experience and creation of music, our senses of smell taste, touch and proprioception, to suggest that our living experience is a product of digital nerve function is insane, a denial of vibrant Living reality.

Further if we accept that consciousness is intrinsic to biology, the sensitivity of organisms being convincing evidence that this is so, the question then becomes where did this consciousness come from? Is it possible that matter is consciousness, biology being this matter becoming more conscious / energetic, waking up to its latent potential, exploring its possibilities, evolving itself? It would also follow that the Universe itself is conscious, biological and biophilic.

“The psyche cannot be totally different from matter for how otherwise could it move matter? And matter cannot be alien to the psyche, or else how could matter produce psyche? Psyche and matter exist in the same world and each partakes of the other, otherwise any reciprocal action would be impossible. If research could advance far enough, therefore, we would arrive at an ultimate agreement between physical and psychological concepts.”

-Carl Jung

 

We don’t know what “matter” ultimately is, the sensitivity demonstrated to be intrinsic to matter by JC Bose, who found that metals subjected to various mechanical, thermal, chemical, and electrical stimuli demonstrated electrical excitatory and fatigue responses similar to living biological material1, suggests that it may be meaningless to attempt to split these concepts, matter and mind.

The evidence for the spontaneous formation of biological life, found by various individuals including Sidney Fox2 and Wilhelm Reich, would suggest that given the right circumstances and stimulus “non-living matter” can somehow learn to reconfigure itself into living forms, suggesting that a primitive consciousness has awoken.

“The dualistic conception of matter as distinct from energy and consciousness is a constrictive illusion put in place by the forces of empire, and the living reality would be freed from the inert husks of the wrongly conceived natural world”.

-Ray Peat.

This could be considered a materialistic proposition, however one that understands that “matter” is something in process, and if so the dream of the Alchemists may be a real  possibility, the “spiritualization” of  “matter”,  making “matter” ever more energetic and ever more consciousness, and with this an increase in the various attributes of consciousness; simplicity, play, purpose, compassion, creativity, insight, and grace. Ever greater freedom, ever more Life.

If consciousness is understood to be the fundamental quality of Life, inseparable from biology, then we are no longer imaged as victims of a genetic lottery adrift in a cold dead universe, but instead active creative participants in the unfolding and expression of both our own psychobiology and that of the living Cosmos that nurtures and supports us.

“The joy of life consists in the exercise of one’s energies, continual growth, constant change, the enjoyment of every new experience. To stop means simply to die. The eternal mistake of mankind is to set up an attainable ideal.”

-Aleister Crowley

Consciousness clearly interacts with biology in a deeply intimate way, anyone who has observed the relationship between breath and psycho-emotional state must have realised this. Multiple studies show that conscious awareness is capable of generating biological changes, increasing the convolutions and surface area of the cerebral cortex, optimizing metabolism, changing brain wave patterns, increasing or decreasing healing, the limits of conscious biopsychic modification are unknown, this is a vast and for the most part unexplored territory, the horizon cannot be seen.

Cracking open the Mundane Shell

Cracking open the Mundane Shell

“We’re supposed to keep evolving, evolution did not end with us growing opposable thumbs.”

-Bill Hicks

 

“God sleeps in stone, breathes in plants, dreams in animals, and awakens in man.”

-Hindu proverb.

 

“He whose face gives no light, shall never become a star.”

-William Blake


[666] “Magick is the Science and Art of causing Change to occur in conformity with Will.”

1 Bose found that metals and living tissues (plant and animal) were all benumbed by cold, intoxicated by alcohol, wearied by excessive work, stupified by anaesthetics, excited by electric currents, stung by physical blows and killed by poison. All exhibit essentially the same phenomena of fatigue and depression, together with possibilities of recovery and of exaltation, as well as the possibility of permanent irresponsiveness, death.

2 “Fox put nearly dry amino acids onto hot volcanic rocks, and when he added a little water, the amino acids polymerized spontaneously, and nonrandomly, into peptide chains; when these were put into water, they spontaneously formed microspheres, that looked like, and behaved very much like, bacteria. Fox saw his work as a validation of the principle that nature itself created higher order spontaneously.”  In Fox’s production of the proteinoid microspheres, the ordered growth is a consequence of the properties of the substance in a permissive environment. The order is not imposed from the outside onto passive matter.

Terence McKenna: psychonaut

“If then you do not make yourself equal to God, you cannot apprehend God; for like is known by like.

Leap clear of all that is corporeal, and make yourself grown to a like expanse with that greatness which is beyond all measure; rise above all time and become eternal; then you will apprehend God. Think that for you too nothing is impossible; deem that you too are immortal, and that you are able to grasp all things in your thought, to know every craft and science; find your home in the haunts of every living creature; make yourself higher than all heights and lower than all depths; bring together in yourself all opposites of quality, heat and cold, dryness and fluidity; think that you are everywhere at once, on land, at sea, in heaven; think that you are not yet begotten, that you are in the womb, that you are young, that you are old, that you have died, that you are in the world beyond the grave; grasp in your thought all of this at once, all times and places, all substances and qualities and magnitudes together; then you can apprehend God.

But if you shut up your soul in your body, and abase yourself, and say “I know nothing, I can do nothing; I am afraid of earth and sea, I cannot mount to heaven; I know not what I was, nor what I shall be,” then what have you to do with God?”

-Hermes Trismegistus

“But to the Eyes of the Man of Imagination, Nature is Imagination itself. As a man is, So he Sees. As the Eye is formed, such are its Powers.”

-William Blake

“I must create a system. or be enslav’d by another mans; I will not reason and compare: my business is to create”

-William Blake

I think Terence is wrong about needing to smash atoms to understand them, but making unusual choices that are outside of established cultural boundaries is a valid psychedelic technique.

Our brain grows into our culture, and the culture lives in our nervous system.

-Ray Peat  (Academic authoritarians, language, metaphor, animals, and science)

“Adaptation to one’s environment makes for a sort of survival; but after all, the supreme victory is only won by those who prove themselves of so much hardier stuff than the rest that no power on earth is able to destroy them. The people who have really made history are the martyrs.”
-Aleister Crowley

For more Terence McKenna check out Lorenzo’s Psychedelic Salon:  http://www.matrixmasters.net/salon/

Consciousness, morphogenetic fields, regeneration, cancer and respiration (in context).

axolotl

The dogmatists insist that life must be explained in terms of physics as they understand it, and it happens that their “physics” is nothing but a doctrinal relic kept in place to justify their conceptions of biology.

-Ray Peat

So I’ve blogged previously about a lot of this, but I think it would be useful to explore these ideas in more detail, as these areas are key to understanding the nature of biological life, as well as presenting solutions to some of the medical problems that the corporatocracy is unwilling to intelligently address.

The conventional view is that an organism’s form is an expression of a “genetic program”, that cancer is produced by rogue clonal genetic mutants, and that organisms capable of regeneration possess magical regeneration “genes” that trigger unconscious regenerative programs. There is good evidence that this biomechanical model is wrong. If an alternative view is adopted, one that examines the issues of morphogenesis, cancer and regeneration in holistic bio-energetic terms then the total organismic environment, respiratory intensity, and consciousness appear to come to the fore as the key issues in understanding these subjects.

In order to think about and understand morphogenesis, cancer and regeneration we need to think in terms of fields or at least field like effects, the current medical culture mired in reductionism neglects such ideas, but developmental fields of various sorts clearly have a functional reality. The essential quality of a field model is holism, a point is influenced by the larger whole in which it finds itself, the organism is a sensitive coherent whole, this is obvious to everyone except the reductionist authorities.

Epigenetic factors play key roles in pattern formation, these include, chemical gradients, electrical gradients, environmental stimuli, cell-cell contacts, all of these factors have in common metabolic processes, including both generation by respiratory processes and the ability to modulate respiration.

These morphogenetic fields are I think manifestations of consciousness. Consciousness, whether or not it can be explained, must be included in a holistic biology, as it is the fundamental attribute of biology, the sensitivity of organisms is consciousness in action, to exclude consciousness as a factor in biology is insanity. An organism is a pattern unfolding in time, oriented by consciousness.

What is metabolism? What is respiration? Understanding these concepts is critical to understanding the nature of life, the way these concepts are often understood in isolation from the organism as a whole can leave people with distorted ideas as to what metabolism and respiration actually are, at least that is the impression I get when I speak to some people about these ideas. The metabolic processes often appear to be understood as some kind of mechanical combustion engine, that burns up fuel like car engine, and that the best way to increase metabolism is engage in mindless exercise.

One of the criticisms often directed at Ray Peat is that he seems to think thyroid is the solution to everything, and hence he must be a quack, because thinking about the possibility of elegant panaceas is unscientific. If you believe that metabolism and life occur through the actions of ion and proton pumps installed in lipid bilayer membranes, then a focus on metabolism might seem as strange as suggesting that you fix a car’s flat tire by installing a new spark plug. So how could supporting thyroid function and improving metabolism correct, say, an arthritic condition?

The current mechanical model of biology, obscures the centrality of metabolism in the maintenance of the organism. This mechanical model leads people to suggest that lowering of metabolism is optimal if you want to achieve longevity, after all continual use of a car will lead to a more rapid breakdown of the parts, thankfully we are not machines.

If a different view of the Life process is taken, wherein Life is seen as a self-organizing dissipative structure, somewhat like a Belousov-Zhabotinsky reaction or a cyclone. In such a model, coherent energy flow (metabolism) becomes on obvious focal point.

Energy and structure

Structure is generated by the energetic “whirlwind” of the respiratory process, distortions/interferences in respiration inevitably lead to structural distortions of one sort or another. However if interfering with respiration distorts structure, then supporting respiration will heal the organism.

 

“The intensity of oxidative metabolism is the basic factor that permits continuing coordination of activity, and the harmonious renewal of all the components of the organism.”

-Ray Peat

When the importance of respiration in healing and morphogenesis is examined it seems clear that the appearance of physicality is superficial, and an energetic reality emerges. Take for example the “injury potential”, where injured tissue will be electrically negative relative to uninjured, this electronic excitation might be more accurately seen as an incoherent discharge, which arises when the coherent energetic flow of the living state is disrupted. As Ray Peat has pointed out the so-called “membrane potential” is just another “injury potential”, the “membrane potential” is measured through piercing the cell with a micro-electrode, and because the cell is injured by this procedure its energetic structure is disrupted, and discharges creating the impression that the inside of the cell is “negative” in comparison to the outside. A sort of energetic decay can be seen, in simple injury, as well as other conditions demonstrating increased “reductive” stress, the “electrons” arise from the energetic disruption. Instead in the uninjured coherent living state the “electrons” are in a state of delocalized charging centripetal flow, manifesting in what is conventionally referred to as a more oxidized state. The nuclear theory of the atom seems questionable. The over reduced state of injury, cancer, as well as the active / dead state of Ling’s AI hypothesis could all be viewed as various degrees of energetic discharge and departure from the charged electronically desaturated living state. Agents such as ATP and CO2 which in Ling’s terminology are electron withdrawing cardinal adsorbents act to restore charge and coherent energy flow.

A thyroid supplement is one possible means of supporting respiratory intensity in an environment that contains many anti-respiratory factors (xeno-estrogens, fluoride, radiation, carrageenan, PUFA, etc).

The problems of cancer and regeneration or the lack of regeneration, are related problems, cancer is an excess of new tissue, which fails to integrate into the organism as a whole. Organisms capable of regeneration are remarkably resistant to cancer, even artificial attempts at inducing cancer in such animals are difficult, tissues exposed to carcinogens normalise rapidly, when tumors are transplanted onto amputated limb stumps of newts they are typically assimilated into a new limb (Oviedo and Beane 2009). This observation seems unremarkable, but if the mechanistic genetic reductionism of the scientific “orthodoxy” is correct the opposite might be expected, organisms whose cells are phenotypically labile, capable of relatively easy de-differention, and swift proliferation, might be expected to be prone to spontaneous cancer generation. However a model that works with a “morphogenetic” field would expect that regeneration and cancer should be inversely related, the field strength required for regeneration would also render cancer unlikely.

The regenerative blastema, a mass of undifferentiated cells, that forms from previously differentiated cells as part of the early regenerative process, shares features of cancer, and such similarities have led to theories that cancer represents an attempt at healing that somehow fails to be controlled by the normal processes of morphostasis.

Embryos also demonstrate significant resistance to cancer, human metastatic melanoma cells transplanted into chick embryos differentiate and function normally within the host (Kulesa et al. 2006). Malignant mouse teratocarcinoma cells were injected into mouse blastocysts (a pre-embyronic developmental form), the tumour cells differentiated into multiple normally functioning tissues, including immune cells, liver cells, and sperm cells, the mice produced were genetic chimeras capable of passing on genetic material from the tumour cells to their progeny, the same teratocarcinoma cells injected subcutaneously in mice form cancers (Mintz and Illmensee 1975). Gestating organisms also display significant regenerative abilities, and scar free healing (Redd et al. 2004).

Given a natural tendency of cells to multiply, the interesting thing about regenerative healing is the question of why the new growth of tissue sometimes differentiates to fit appropriately into its surroundings, but sometimes fails to differentiate, becoming a tumor.

-Ray Peat.

There is now good evidence that the old idea that cancer is tissue that has escaped from the organising pattern of the individuation field is correct, the differentiation of cells is dependent on environmental signals, isolated cells are known to lose most functional differentiation when separated and placed in traditional cell cultures. Breast cancer cells implanted into in vitro tissue matrices containing collagen, fibroblasts, and basement membrane demonstrated near complete phenotype reversion, becoming more differentiated (Krause et al. 2010). The ability of the larger tissue environment to normalise cancer cells clearly demonstrates that cancer is a problem of organisational signalling.

This organizing field can be seen in regeneration and morphogenesis, in study where developmental defects were induced in tadpoles, by manipulating the embryonic voltage gradients that guide craniofacial patterning, displacing jaws and branchial arches, subsequent development was able to adjust and reshape to correct these perturbations (Vandenberg et al. 2012). Clearly morphogenesis is a dynamic holistic patterning process.

I think it is likely that morphogenesis and regeneration are examples of intelligence in the organism, they are guided by consciousness, no doubt this stinks of vitalism. The typical explanations for regeneration and morphogenesis rely on cascades of molecular signaling read out from genetic code, but this sort of reductionism fails to explain anything meaningful.

In a number of studies it has been shown that denervation results in the loss of regenerative capacity, although regeneration continues as normal if the nerve regenerates (Singer 1952). A study found that higher nerve quantity relative to non-nerve tissue was positively associated with regeneration in frogs, small young froglets, with a higher quantity of innervation were capable of regeneration, larger froglets and adults, with about half the innervation quantity of their smaller counterparts were completely devoid of regenerative capacity, however if their innervation was increased by deviating sciatic nerve bundles to the forelimb stump, almost all limbs which were usually non-regenerative with normal innervation demonstrated at least some regeneration (Kurabuchi 1992). The role of the nervous system in regeneration is further supported by observations that the regenerating limbs of newts, have a greater quantity of innervation (axoplasm of nerve per area of limb cross-section) than the normally non-regenerating limb of adult frogs. These studies might explain to some extent the increased regenerative capacity of young animals including human children who are recorded as having have regenerated finger tips, when the wound has not been stitched up by medical authorities. Young animals have a proportionally greater degree of nerve tissue.

If innervation (nerve supply) is involved in regeneration and there is a relationship between regeneration and cancer, denervation should affect carcinogenesis, multiple studies suggest that it does. Rats subjected to subdiaphragmatic truncal vagotomy developed tumors and carcinoma of the gastric mucosa (Kaminishi et al. 1995), denervation of sensory nerves with capsaicin increased tumor metastases of the heart and lungs in mice (Erin et al. 2004). Denervation has other effects on tissue, causing increased excitability and muscle spasm, inducing atrophy in muscles, changes in vascularization including narrowing of the lumen of arterioles increased collagen deposition, and capillary necrosis (Carpenter and Karpati 1982, and Borisov et al. 2000), denervation increases mast cells (de Morais et al. 2008). Denervation also causes changes to mitochondria, decreasing the activity of respiratory enzymes including cytochrome oxidase, decreasing cardiolipin (Wicks and Hood 1991), in muscle tissue denervation reduces mitochondrial size, leads to changes in mitochondrial arrangements, with mitochondria becoming less organized (Miledi and Slater 1968).

Interestingly height in humans is positively associated with cancer, tall people get more cancer, it is possible the ratio of brain and nerve tissue to body size play a similar role here as it appears to with regenerative capacity (Green et al. 2011).

Given that nerve supply plays a clear role in morphostasis, promoting regeneration, differentiation, and inhibiting cancer, as well as exerting trophic effects preventing tissue atrophy, the suggestion that consciousness might be intimately involved in these processes does not seem unreasonable, unless there is an irrational adherence to an ideology that claims that consciousness is an illusionary ghost in the machine of biology. The idea that consciousness is involved in healing is supported by a study where the rate of healing was lower in individuals with poor anger control, these individuals also had higher cortisol levels when wounded (Gouin et al. 2008).

I think some studies showing that denervation increases lactate and reactive oxygen species (ROS) production (Karpati et al. 1979, and Muller et al. 2007), and a study showing that meditation decreased lactate (Perez-De-Albeniz and Holmes 2000) suggest that it is consciousness that centres the respiratory whirlwind, and that consciousness is capable of increasing the coherence of energy flow and cytoplasmic microstructure, evidenced in reduced plasma lactate.

There are studies (McCaig and Rajnicek 1991) demonstrating that nerves grow towards cathodes (negative polarity) this seems to suggest that the conscious organism senses the energetic discharge (negative polarity) produced by injury and that the nerves as potential regulators of the morphogenetic field grow towards it in an attempt at restoring coherence. Cancer cells have also been shown in one study to migrate towards cathodes (Yan et al. 2009), this might support the idea that cancer is in some way an attempt at healing. Robert Becker and others have studied the electrical properties of wounds and regenerating tissue, they have also succeeded in inducing incomplete regeneration in rats using implanted bimetallic electrogenic devices to simulate the electrical environment in the tissues of regenerative animals such as salamanders, the rats regenerated missing portions of the humeral shaft along with differentiated muscle tissue (Becker and Spadaro 1972).

Becker (1960), has also shown that the central nervous system appears to be intimately involved in the bioelectric fields generated by organisms, the spatial organization of the field correlated with the morphology of the central nervous system, areas of nerve cell aggregations in the central nervous system appear to serve as both sources and sinks of the potential, with transmission along major nerve trunks. Becker concluded that the dc bioelectric potential in organisms may be generated within and conducted by portions of the central nervous system. Borgens disagrees with Becker arguing that denervation was associated with increased current leaving the amputated limb (Borgens et al. 1979), I think there might be a way of reconciling this apparent contradiction, with the nervous system acting in some way to structure the total bioelectric field.

Interestingly the “immune system” also appears to play a role in regeneration, macrophage depletion of axolotls resulted in failure of limb regeneration, the wound closed over with extensive fibrosis, if macrophages were restored and the stump re-cut regeneration occurred (Godwin et al. 2013). I think this study supports the idea that the “immune system” might more accurately be described as a morphostatic “clean up the mess” system as Jamie Cunliffe has proposed (http://www.morphostasis.org.uk/). A new perspective on the “immune system” might lead to some rational thinking about and solutions to the so-called “auto-immune” diseases.

Predictably (the lymphoid organs are innervated by sympathetic nerves) denervation also affects immune function, reducing generation of cytotoxic T-lymphocytes and mobilisation of macrophages (Leo et al. 1998, and Richards et al. 1999).

When respiration is inhibited energy ceases to flow, or its flow slows and stagnates, this inhibited flow leads to weakening of the morphogenetic fields, structural disruption, inflammation, swelling, and in more extreme cases cancer and tissue atrophy/death. Many pesticides interfere with mitochondrial metabolism, these pesticides have been linked to neural tube defects (Rull et al. 2006), TCDD (a dioxin) a known carcinogen induces mitochondrial dysfunction, triggering calcium uptake by the cell, and increased ROS, cells became more invasive (Biswas et al.2008). Altered mitochondrial bioenergetics have been linked to cancer since Otto Warburg’s observation that cancer was associated with increased rates of aerobic glycolysis, linking this to some sort of loss of structure within the cell, realising that mitochondrial oxidation involved a greater degree of structure than the simpler fermentation of glycolysis. Recent studies also link mitochondrial function to tumour initiation, invasiveness and regression, with mitochondrial dysfunction producing changes in extracellular matrix modelling (van Waveren et al. 2006). This ability of cancer cells to alter the extracellular matrix supports the idea of a “cancer field” wherein the distorted metabolism of cancer cells generates further distortion in the surrounding tissue, cells bordering on metastases display structural abnormalities (Correa et al. 1998).

Evidence for altered structural properties of cancer cells was found by Raymond Damadian who examined tumour cells with magnetic resonance (NMR) and found increased relaxation times for the water in cancer ells suggesting that it is in a less structured state than water in non-cancer cells, Damadian’s inspiration in examining this was the work of Gilbert Ling (Damadian 1971). Ling’s work has already been mentioned previously on this blog, given the central role of ATP in stabilising the protein-water matrix of the cytoplasm, cancer cells with there characteristic metabolic dysfunction would be expected to show signs of structural disturbance.

Respiration guided by consciousness is the organizing force, when this force is inhibited disease results.

Therapeutics:

The ability to trigger re-differentiation of cancer cells has been virtually ignored by mainstream medicine, but this capacity seems to radically question the idea that cancer is produced by genetic mutations, as the dogma would suggest that if so cancer cells should after mutation be forever determined in their identity.

Given the facts of spontaneous remission and the in vitro inducible cellular re-differentiation of cancer cells into non-cancer cells, as well as the resistance of highly regenerative animals to cancer, an alternative therapeutic approach seems to be possible, instead of the heroic “cut, burn and poison” mode of warfare on the evil mutant cancer monster.

 

“If cancers were werewolves, the cancer industry’s search for more refined killing technologies might be going in the right direction. But the genetic doctrine of cancer’s origin is just as mythical as werewolves and vampires.”

-Ray Peat

Possible practical strategies to take in optimising healing both of injury and cancer would aim at increasing the coherence and strength of the morphogenetic fields, much of this has been discussed previously on this blog (and of course in Ray Peat’s work). Restoration of efficient mitochondrial metabolism being paramount in assisting in differentiation.

Therapeutics would include; meditation to increase conscious inhabitation of our nervous system, promoting a further development of the nervous system, which should increase the trophic morphogenetic aspect of nerve function. Reduced breathing practices such as pranayama and Buteyko technique, to increase carbon dioxide and efficiency of oxygen utilisation. There is also evidence suggestive of a role of carbon dioxide in regenerative processes, it protects the lungs prophylactically from endotoxin induced injury and appears therapeutic post injury (Laffey et al. 2004). Carbon dioxide inhibits lactate formation (Cohen et al. 1990), and appears to shift the cell towards a more “oxidized” state with increased NAD+/NADH ratio (Gyulai et al.1982), cancer cell typically appear more “reduced” favouring NADH (Pelicano et al. 2006). Further carbon dioxide interacts with collagen increasing its ability to structure water, this likely also means the collagen becomes a more coherent communicator, allowing for effective morphogenetic signalling (Specchio et al. 1988). This evidence strongly supports the view of carbon dioxide as a doping agent / cardinal adsorbent / kosmotrope that increases our charge, conductivity and coherence.

Dietary avoidance of anti-metabolic substances would also be useful, these include polyunsaturated fatty acids (vegetable oils, most nuts and seeds and fish oil), inflammatory amino acids such as cysteine, methionine, and tryptophan, found in muscle meats, the typical cuts of meat usually eaten in western diets. Certain food contaminants common in processed foods such as carragenaan should also be avoided.

Supplemental use of adaptogenic herbs, and possible careful use of hormonal treatments such as thyroid, as experimentally induced hyper-thyroidism appears to be able to speed healing and regeneration of neurons (McIsaac and Kiernan 1975 and Lewin-Kowalik et al. 1993), and thyroid hormone speeding wound healing (Safer et al.2005). Neurosteroids such as pregnenolone, progesterone and DHEA due to their generally stabilising effects both on nerve and other cells might also be useful.

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Axolotl photo: Tim Flach http://www.timflach.com/